Intestinal Motility Disorders Medication: Cholinergic Agonists, Prokinetic Agents, Opioid Reversal Agents, Antidiarrheals, Antibiotics, Acetylcholinesterase Inhibitors, Secretagogues (2024)

Author

Mia L Manabat, DO Gastroenterologist, Aurora Health Care

Mia L Manabat, DO is a member of the following medical societies: American College of Osteopathic Internists, American Osteopathic Association

Disclosure: Nothing to disclose.

Coauthor(s)

Michael H Piper, MD Clinical Assistant Professor, Department of Internal Medicine, Division of Gastroenterology, Wayne State University School of Medicine; Consulting Staff, Digestive Health Associates, PLC

Michael H Piper, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Gastroenterology, American College of Physicians, Michigan State Medical Society

Disclosure: Nothing to disclose.

Chief Editor

Burt Cagir, MD, FACS Associate Regional Dean and Professor of Surgery, Geisinger Commonwealth School of Medicine; Director, General Surgery Residency Program, Executive Director, Donald Guthrie Foundation for Research and Education, Guthrie Robert Packer Hospital; Medical Director, Guthrie/RPH Skills and Simulation Lab; Associate in Surgery, Guthrie Robert Packer Hospital and Corning Hospital

Burt Cagir, MD, FACS is a member of the following medical societies: American College of Surgeons, Association of Program Directors in Surgery, Society for Surgery of the Alimentary Tract

Disclosure: Nothing to disclose.

Additional Contributors

Vivek V Gumaste, MD Associate Professor of Medicine, Mount Sinai School of Medicine of New York University; Adjunct Clinical Assistant, Mount Sinai Hospital; Director, Division of Gastroenterology, City Hospital Center at Elmhurst; Program Director of GI Fellowship (Independent Program); Regional Director of Gastroenterology, Queens Health Network

Vivek V Gumaste, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association

Disclosure: Nothing to disclose.

Nafisa K Kuwajerwala, MD Staff Surgeon, Breast Care Center, William Beaumont Hospital

Nafisa K Kuwajerwala, MD is a member of the following medical societies: American College of Surgeons, American Society of Breast Surgeons, American Society of Breast Disease

Disclosure: Nothing to disclose.

Luigi Santacroce, MD Assistant Professor, Medical School, State University at Bari, Italy

Disclosure: Nothing to disclose.

Venkata Subramanian Kanthimathinathan, MD Fellow in Bariatric/Advanced Laparoscopic Surgery, University of Missouri Healthcare

Disclosure: Nothing to disclose.

Acknowledgements

Silvia Gagliardi, MD Consulting Staff, Department of Surgery, Medical Center Vita, Italy

Disclosure: Nothing to disclose.

Douglas M Heuman, MD, FACP, FACG, AGAF Chief of GI, Hepatology, and Nutrition at North Shore University Hospital/Long Island Jewish Medical Center; Professor, Department of Medicine, Hofstra North Shore-LIJ School of Medicine

Douglas M Heuman, MD, FACP, FACG, AGAF is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Physicians, and American Gastroenterological Association

Disclosure: Novartis Grant/research funds Other; Bayer Grant/research funds Other; Otsuka Grant/research funds None; Bristol Myers Squibb Grant/research funds Other; Scynexis None None; Salix Grant/research funds Other; MannKind Other

Sandeep Mukherjee, MB, BCh, MPH, FRCPC Associate Professor, Department of Internal Medicine, Section of Gastroenterology and Hepatology, University of Nebraska Medical Center; Consulting Staff, Section of Gastroenterology and Hepatology, Veteran Affairs Medical Center

Sandeep Mukherjee, MB, BCh, MPH, FRCPC is a member of the following medical societies: Royal College of Physicians and Surgeons of Canada

Disclosure: Merck Honoraria Speaking and teaching; Ikaria Pharmaceuticals Honoraria Board membership

Shivkumar Prabhu, MD Consulting Staff, Department of Internal Medicine, St John Detroit Riverview Hospital

Disclosure: Nothing to disclose.

Daniel Schafer Department of Surgery, University of Nebraska Medical Center

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Intestinal Motility Disorders Medication: Cholinergic Agonists, Prokinetic Agents, Opioid Reversal Agents, Antidiarrheals, Antibiotics, Acetylcholinesterase Inhibitors, Secretagogues (2024)

FAQs

What medication is used to improve intestinal motility? ›

Drugs used in the management of intestinal motility disorders include parasympathomimetics, prokinetic agents, opioid antagonists, antidiarrheals, and antibiotics. The agents that are most useful in the treatment of these disorders are neostigmine, bethanechol, metoclopramide, cisapride, and loperamide.

What cholinergic drugs are used for intestinal motility? ›

These drugs mimic acetylcholine, a neurotransmitter that stimulates your intestinal muscles to contract. Examples include baclofen, bethanechol, neostigmine and pyridostigmine. Motilin agonists (macrolide antibiotics). These drugs mimic motilin, a neurotransmitter that stimulates contractions in your small intestine.

Is intestinal motility disorder fatal? ›

Many motility disorders have no known cause but are very common (such as IBS). Some are less common but can be life-threatening, such as gastroparesis or intestinal pseudo-obstruction.

What is a motility disorder in the intestines? ›

“Motility disorders” is an umbrella term that encompasses many conditions that can affect the different parts of the intestinal tract. In essence, the cause of these motility disorders is a dysfunction of either the nerves or muscles that leads to the intestinal muscles contracting or relaxing improperly.

How do you fix poor gut motility? ›

Research suggests that probiotics, prebiotics, synbiotics, antibiotics, and fecal transplants can effectively improve chronic constipation with few side effects. Probiotic consumption via fermented foods and/or supplementation can help to rebalance the intestinal microbiota and improve gut motility.

What is the best treatment for slow bowel motility? ›

Treatment for slow transit constipation

Treatment options may include: medication to improve bowel motility. regular enemas to flush the rectum of faeces. interferential electrical stimulation therapy (used in what is known as the TIC TOC treatment trial).

What supplements help with gut motility? ›

Supplements such as magnesium, fiber, probiotics, and senna may be particularly helpful. However, many supplements interact with certain medications and may lead to adverse effects if you use them incorrectly. As such, talk with your doctor about supplements for constipation relief to find the best option for you.

What medication is used for intestine movement? ›

Take over-the-counter medicines
  • fiber supplements (Citrucel, FiberCon, Metamucil)
  • osmotic agents (Milk of Magnesia, Miralax)
  • stool softeners link (Colace, Docusate)
  • lubricants, such as mineral oil (Fleet)
  • stimulants (Correctol, Dulcolax)

What drugs intensify gastrointestinal motility? ›

Abstract. Studies in animals and man have shown that metoclopramide, bethanechol and domperidone enhance the peristaltic contractions of the esophageal body, increase the muscle tone of the lower esophageal sphincter, and stimulate gastric motor activity.

What medication is used for chronic pseudo-obstruction? ›

Neostigmine may be used to treat intestinal pseudo-obstruction that is only in the large bowel (Ogilvie syndrome). Special diets often do not work. However, vitamin B12 and other vitamin supplements should be used for people with vitamin deficiency.

Is intestinal dysmotility curable? ›

Specific treatments are available for some causes of dysmotility, including abnormalities in salt balance and endocrine problems such as thyroid disease. Unfortunately, many causes of dysmotility cannot be cured, and symptomatic treatment is offered.

Is intestinal dysmotility rare? ›

Abstract. Chronic intestinal dysmotility is a rare and debilitating digestive disorder characterized by symptoms of mechanical obstruction without an organic lesion. It has diverse causes and involves various pathological mechanisms.

What are the best motility drugs? ›

The agents that are most useful in the treatment of these disorders are neostigmine, bethanechol, metoclopramide, cisapride, and loperamide.

Is motility disorder autoimmune? ›

Autoimmune gastrointestinal dysmotility (AGID) is a limited form of dysautonomia that affects digestive tract motility. Although rare, the condition can be debilitating, with individuals experiencing nausea and dramatic weight loss.

What are the symptoms of Hyperperistalsis? ›

Increased peristalsis is called hypermotility or hyperperistalsis. It leads to diarrhea and problems with digestion when the GI tract doesn't have enough time to break food down properly and absorb its nutrients.

Intestinal Motility Disorders Treatment ...Medscape eMedicinehttps://emedicine.medscape.com ›

In selected patients, pharmacotherapy may be helpful. Gastric preprandial dysrhythmia may lead to impaired gastric emptying, thus contributing to irregular abso...
Have you ever experienced digestive problems? People all over the world commonly suffer from acute digestive problems such as stomach aches, diarrhea, constipat...
ReferencesWhitehead WE. Gastrointestinal Motility Disorders of the Small Intestine, Large Intestine, Rectum, and Pelvic Floor. IFFGD Fact Sheet No. 162; 2001.

Which drug increases gastrointestinal motility? ›

Abstract. Studies in animals and man have shown that metoclopramide, bethanechol and domperidone enhance the peristaltic contractions of the esophageal body, increase the muscle tone of the lower esophageal sphincter, and stimulate gastric motor activity.

What increases intestinal motility? ›

Eat more fiber. Fiber-rich foods such as whole grains, leafy vegetables and fresh fruits will add bulk to your feces and help stimulate the bowel to push food along. Because a quick addition of fiber to your diet can result in gas, bloating and cramps, it should gradually be introduced over time.

How do you treat intestinal dysmotility? ›

Unfortunately, many causes of dysmotility cannot be cured, and symptomatic treatment is offered. Medicines can stimulate intestinal motility and help with propulsion of intestinal contents. Dietary modifications are advised. It is important that adequate calories are taken, usually in the form of meal supplements.

What medicine is a gastroparesis gut motility stimulator? ›

Metoclopramide. This is the only FDA-approved medication to treat gastroparesis. It stimulates muscle contractions in your stomach and can also help relieve nausea. However, it comes with a black-label warning because it can cause neurological side effects, including tremors and muscle twitching.

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