Semaglutide (Subcutaneous Route) Precautions - Mayo Clinic (2024)

Precautions

Drug information provided by: Merative, Micromedex®

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Tell your doctor if you are pregnant or planning to become pregnant. Do not use this medicine for at least 2 months before you plan to become pregnant.

It is very important to carefully follow any instructions from your health care team about:

  • Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.
  • Other medicines—Do not take other medicines during the time you are using semaglutide unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.
  • Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, diabetic patients may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur during pregnancy in patients with diabetes.
  • Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.

In case of emergency—There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines.

This medicine may increase the risk of having thyroid tumors. Tell your doctor right away if you have a lump or swelling in your neck or throat, trouble swallowing or breathing, or if your voice gets hoarse.

Pancreatitis (swelling of the pancreas) may occur while you are using this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Check with your doctor right away if you have gaseous stomach pain, indigestion, recurrent fever, severe nausea or vomiting, stomach fullness, or yellow eyes or skin. These may be symptoms of gallbladder problems (eg, cholelithiasis, cholecystitis).

This medicine may cause diabetic retinopathy. Check with your doctor if you have blurred vision or any other changes in vision.

This medicine does not cause hypoglycemia (low blood sugar). However, low blood sugar can occur when you use semaglutide with other medicines, including insulin or sulfonylureas, that can lower blood sugar. Low blood sugar also can occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting.

  • Symptoms of low blood sugar include anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty with thinking, drowsiness, excessive hunger, fast heartbeat, headache (continuing), nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness.
  • If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes, or drink fruit juice, non-diet soft drink, or sugar dissolved in water to relieve the symptoms. Also, check your blood for low blood sugar. Glucagon is used in emergency situations when severe symptoms including seizures or unconsciousness occur. Have a glucagon kit available, along with a syringe and needle, and know how to use it. Members of your family should also know how to use it.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.

This medicine may cause acute kidney injury. Check with your doctor right away if you have a bloody urine, decreased urine output, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

This medicine may increase your heart rate while you are at rest. Check with your doctor right away if you have fast or pounding heart beat.

Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your antidiabetic medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual.

  • Symptoms of high blood sugar include blurred vision, drowsiness, dry mouth, flushed, dry skin, fruit-like breath odor, increased urination (frequency and amount), ketones in the urine, loss of appetite, stomachache, nausea or vomiting, tiredness, trouble breathing (rapid and deep), unconsciousness, or unusual thirst.
  • If symptoms of high blood sugar occur, check your blood sugar level and then call your doctor for instructions.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Also tell your doctor if you have sudden or strong feelings, including feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

  • Proper Use
  • Side Effects

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

.

Semaglutide (Subcutaneous Route) Precautions - Mayo Clinic (2024)

FAQs

Semaglutide (Subcutaneous Route) Precautions - Mayo Clinic? ›

This medicine may cause acute kidney injury. Check with your doctor right away if you have a bloody urine, decreased urine output, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

What is the half life of semaglutide subcutaneous? ›

Semaglutide has a half-life of around 1 week. This means it takes 5-7 weeks to be eliminated from the system after the last dose. Complete washout requires 8-10 weeks. The prolonged persistence enables stable blood glucose control and sustained weight loss with only weekly injections.

What is the dark side of semaglutide? ›

Pancreatitis (swelling of the pancreas) may occur while you are using this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

What are the clinical guidelines for semaglutide? ›

Semaglutide naive: For semaglutide-naive patients, the recommended dosing regimen starts with 0.25 mg weekly for 4 weeks, followed by a dose escalation to 0.5 mg weekly. The 0.5-mg weekly dosage can be escalated to 1 mg weekly if glycemic control is inadequate after 4 weeks on the 0.5 mg/week dosage.

Is there a wrong way to inject semaglutide? ›

Don't inject it into injured, swollen, or scarred parts of your skin. It simply needs to be in a thick, fatty area of your skin. Don't inject semaglutide into your veins or muscles. While some people might rotate body parts, others choose to stick with the same injection site (such as the stomach).

What happens if you inject semaglutide into muscle? ›

When injecting semaglutide, it is vital to ensure that the medication is not injected into muscles or veins. Injecting any medication directly into a muscle can cause increased absorption and intense metabolization of the drug, leading to an overdose or side effects.

How to flush semaglutide out of your system? ›

There's no specific antidote for a semaglutide overdose. The drug has a half-life of about a week, meaning it takes one week to clear half of it from your body.

How long can semaglutide vial stay out of the fridge? ›

Semaglutide can stay out of the fridge for 56 days at a controlled room temperature.

How long does it take for semaglutide to suppress appetite? ›

How Long Do I Need to Take Semaglutide To See Results? The timeline for seeing results with semaglutide can vary from person to person, but most people begin to experience the appetite-suppressing effects within the first four to eight weeks of starting the medication.

Is semaglutide hard on the liver? ›

Thus, liver injury due to semaglutide must be rare, if it occurs at all. Likelihood score: E (unlikely cause of clinically apparent liver injury).

What can you not do on semaglutide? ›

Here are the top five foods to avoid while taking semaglutide.
  • Foods That Are High in Fat. Eating foods high in fat can worsen the common side effects of semaglutide. ...
  • Sugary Foods. ...
  • Refined Carbohydrates. ...
  • Starchy Vegetables. ...
  • Excessive Alcohol.
Mar 7, 2024

Why am I so tired on semaglutide? ›

Semaglutide works for weight loss by making you feel less hungry. And eating fewer calories may cause you to feel more tired. Feelings of fatigue should subside as your body adjusts to potential changes in your diet.

What drugs cannot be taken with semaglutide? ›

Other medicines—Do not take other medicines during the time you are using semaglutide unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.

What is the black box warning for semaglutide? ›

The FDA noted that the semaglutide label has a boxed warning about the risk of thyroid C-cell tumors, saying the drug shouldn't be used in patients with a personal or family history of medullary thyroid carcinoma or in those with multiple endocrine neoplasia syndrome type 2.

What is the antidote for semaglutide? ›

There is no specific antidote for overdose with semaglutide. In the event of overdose, appropriate supportive treatment should be initiated according to the patient's clinical signs and symptoms.

Where is the best place to inject semaglutide for weight loss? ›

Injecting into these fatty layers allows for comfortable injections and proper absorption of the drug. Some of the best areas for semaglutide injections are the thighs and the abdomen around the belly button. Both the thighs and abdomen provide padding from fat so the injections do not hit nerves or muscle.

What angle do you inject semaglutide? ›

Injecting the medication – hold the syringe at a 90-degree angle to the skin, insert a new needle swiftly and steadily, inject the medication and hold for a few seconds before you remove the needle. Dispose of supplies – safely dispose of the used needle and any other materials.

Is semaglutide subcutaneous or intramuscular? ›

Semaglutide injection comes as a solution (liquid) in a prefilled dosing pen to inject subcutaneously (under the skin). It is usually injected once a week without regard to meals.

Should you eat before injecting semaglutide? ›

Use this medicine on the same day each week, at any time of the day, with or without meals.

Top Articles
Budget HeartKeeper Unkillable - DeadwoodJedi - Raid Shadow Legends
Useful Tools for Raid: Shadow Legends - HellHades
Artem The Gambler
UPS Paketshop: Filialen & Standorte
Ffxiv Shelfeye Reaver
Combat level
How To Do A Springboard Attack In Wwe 2K22
Health Benefits of Guava
Fully Enclosed IP20 Interface Modules To Ensure Safety In Industrial Environment
Tv Schedule Today No Cable
About Goodwill – Goodwill NY/NJ
Corporate Homepage | Publix Super Markets
Sitcoms Online Message Board
Mawal Gameroom Download
‘Accused: Guilty Or Innocent?’: A&E Delivering Up-Close Look At Lives Of Those Accused Of Brutal Crimes
ExploreLearning on LinkedIn: This month's featured product is our ExploreLearning Gizmos Pen Pack, the…
How Much Is Tj Maxx Starting Pay
Les Schwab Product Code Lookup
Craigslist Farm And Garden Cincinnati Ohio
Define Percosivism
Who called you from +19192464227 (9192464227): 5 reviews
NBA 2k23 MyTEAM guide: Every Trophy Case Agenda for all 30 teams
Ruben van Bommel: diepgang en doelgerichtheid als wapens, maar (nog) te weinig rendement
Schedule An Oil Change At Walmart
Tu Pulga Online Utah
Craigslist Lewes Delaware
Used Safari Condo Alto R1723 For Sale
Azur Lane High Efficiency Combat Logistics Plan
Foolproof Module 6 Test Answers
Copper Pint Chaska
Roadtoutopiasweepstakes.con
The Menu Showtimes Near Amc Classic Pekin 14
Jay Gould co*ck
24 slang words teens and Gen Zers are using in 2020, and what they really mean
20 Best Things to Do in Thousand Oaks, CA - Travel Lens
Aliciabibs
Planet Fitness Santa Clarita Photos
Felix Mallard Lpsg
Search All of Craigslist: A Comprehensive Guide - First Republic Craigslist
Sdn Fertitta 2024
Ucla Basketball Bruinzone
Killer Intelligence Center Download
Paperlessemployee/Dollartree
Nearest Wintrust Bank
Canvas Elms Umd
tampa bay farm & garden - by owner "horses" - craigslist
Doelpuntenteller Robert Mühren eindigt op 38: "Afsluiten in stijl toch?"
Publix Store 840
March 2023 Wincalendar
Black Adam Showtimes Near Cinemark Texarkana 14
Craigslist.raleigh
Coors Field Seats In The Shade
Latest Posts
Article information

Author: Domingo Moore

Last Updated:

Views: 5617

Rating: 4.2 / 5 (73 voted)

Reviews: 80% of readers found this page helpful

Author information

Name: Domingo Moore

Birthday: 1997-05-20

Address: 6485 Kohler Route, Antonioton, VT 77375-0299

Phone: +3213869077934

Job: Sales Analyst

Hobby: Kayaking, Roller skating, Cabaret, Rugby, Homebrewing, Creative writing, amateur radio

Introduction: My name is Domingo Moore, I am a attractive, gorgeous, funny, jolly, spotless, nice, fantastic person who loves writing and wants to share my knowledge and understanding with you.